In a September 28, 1997 special to the Washington Post...
"I don't believe in Heaven and Hell," he says. "I don't know if I believe in God. All I know is that as an individual, I won't allow this life -- the only thing I know to exist -- to be wasted."
From Larry King Live February 16, 2006:
King: Did you lose your faith, or do you still have it?
Clooney: I don't have a specific....Yeah...I don't....You know. It's an interesting thing. I'll tell you what's tricky about this. In talking about religion, if you're well known, anything you say, it sort of takes off about a bunch of other people and attacks their belief. So I always try to say that, you know, first and foremost, that whatever anybody believes as long as it doesn't hurt anybody else, it's fair enough, and works, and I think, is real, and matters. I don't happen to have those beliefs, as much, you know, I don't believe in those things.